Avox 1.2gm is a combination of amoxicillin and potassium clavulanate. Amoxicillin is medium spectrum, bacteriolytic, β-lactum antibiotic with Aminopenicillin family. It is used to treat both Gram negative and Gram positive bacteria. Potassium Clavulanate is a β-lactum antibiotic, mainly functions by β-lactumase inhibitor. It is mostly combined with Amoxicillin and Ticarcillin.
- Severe infections caused by bacteria
- ENT infections caused by caused due streptococcus bacteria
- Infections in genitourinary tract
- Skin and skin structure infections
- Triple therapy for H.pylori
- Gonorrhea, acute uncomplicated (ano-genital and urethral infections in males and females)
1.2gm every 8 hrs
Amoxicillin involves the inhibition of synthesis of cell wall synthesis. The inhibition of cross-linkage between linear peptidoglycan polymer chains that make up a major component of the cell walls of both Gram-positive and Gram-negative bacteria. Potassium clavulanate is having antimicrobial activity, because of the same chemical structure which facilitates the molecule to interact with β-lactamase secreted by particular bacteria to a particular bacteria to confer resistance to β-lactam antibiotics. It binds covalently to the active site of β-lactam i.e serine residue. This increases the activity of Potassium Clavulanate which inhibits enzyme activity.
After administration it is well absorbed in body, about 74-93% is absorbed in GI tract. After administration 93% of the drug is absorbed.
The distribution is through tissue and fluids. Lower concentrations were attained in cerebrospinal fluid. It can cross placenta and can even pass into human milk. The metabolism of the drug takes place in liver.
50-80% of the drug is excreted in urine and other through kidney by glomerular filtration and tubular secretion.
The drug after administration is well absorbed in the body. The serum concentration of Potassium clavulanate is 3.4±1.4 mg/l and 2.8±1.1 mg/l.
It is well absorbed in the body and metabolized through liver. The half-life of the drug is attained in 1hr.
About 30-40% of the drug excretion through kidney.
- Patient with the previous history of hypersensitive reaction should not be prescribed with such drug.
- Patient with previous hepatic dysfunction (Cholestatic jaundice)
- Stevens-Johnson syndrome
- Prolong use of drug causes anaphylaxis
- Can cause Hepatic dysfunctions
- Discontinue the use, if severe reaction occurs
- Discontinue the use, if skin rash occurs
- Over use even cause drug resistant to bacteria