Meropenem is ultra – broad spectrum injectable antibiotic. It comes under β – lactum and belongs to the subgroup of carbapenem. Meropenem produces similar action like impenem and cilastin.
- It is a broad spectrum antibiotic for the treatment of many Gram-positive and Gram-negative bacteria (including Pseudomonas) and anaerobic
- It is more active against enterobacteriaceae
- Resistant to extended spectrum β – lactamase
- It is used for the treatment of febrile neutropenia
- Complicated skin and skin structure infections
- Complicated intra-abdominal infections
- Bacterial meningitis
- Complicated appendicitis and Peritonitis
500 mg IV every 8 hours
Meropenem produces its action as bactericidal. Bacteria cannot sustain without bacterial cell- wall, Meropenem inhibits the bacterial cell wall synthesis. It is highly resistant to degradation by β-lactamase or cephalosporinase. Meropenem is stable with dehydropeptidase – 1and can be given with cilastatin.
Meropenem is administered by I.V infusion to the patient. It gets well absorbed in the body by end of thirty minutes.
After I.V administration of single dose of Meropenem, Cmax attained is approximately 49mcg/ml. Repetitive administration doesn’t cause any accumulation with renal function.
It distributes well in the body, through body fluids and tissues including cerebrospinal fluid. The highest mean concentration achieved in 1 hr.
The elimination half life is 1hr. The drug is excreted in unchanged form in urine. 70% of the drug is excreted in unchanged form in 12hrs.
- It is contraindicated in hypersensitive patients.
- Patients which shows anaphylactic reaction with to β – lactums
- Renal dysfunction
- Decreased blood platelets
- Patients showing anaphylactic reaction.
- Sensitive reaction in patients with β – lactum therapy.
- Patients reported hypersensitivity with penicillin shows severe reactions when treated with β – lactum.