Movogesic-AQ injection2018-12-08T08:45:09+00:00
Movogesic-AQ criticare product

Movogesic-AQ injection contains diclofenac sodium 75 mg is a no steroidal anti-inflammatory drug (NSAID), a phenyl acetic acid derivatives with analgesic, antipyretic and anti-inflammatory activity.

  • management of mild to moderate pain
  • Management of moderate to severe pain alone or in combination with opioid analgesics.
  • Rheumatoid Arthritis
  • Osteoarthritis
  • Ankylosing Spondylitis
  • Dysmenorrheal
  • Migraine
  • kidney stone pain

Movogesic AQ Injection is provided as a solution for injection, containing 75 mg Diclofenac sodium in 3 ml, to be given by intramuscularly or intravenously as an infusion.

Diclofenac action by inhibition of prostaglandins synthesis by inhibition of   cyclooxygenase (COX). Prostaglandins are produced at sites of injury or damage causing pain and inflammation. Diclofenac by blocking the effect of COX enzymes, reduce the prostaglandin formation, which means pain and inflammation are eased.

Absorption

Diclofenac is 100% absorbed orally compared to IV administration. Undergoes first pass metabolism, only 50-60% of a dose reaches systemic circulation as unchanged drug .peak plasma concentration usually attain within about 1hr.

Distribution

The apparent volume of distribution (V/F) of diclofenac sodium is 1.4 L/kg.

Diclofenac is more than 99% bound to human serum albumin. It diffuses into and out of the synovial fluid. Thereby therapeutic concentrations of drug are achieved into the synovial fluid.

Metabolism

Metabolized in liver by hydroxylation and conjugation.

Excretion

Excreted in urine 65% & in feces via biliary elimination 35% as metabolites.

Movogesic AQ is contraindicated in the following patients:

  • Anemia
  • Asthma
  • High blood pressure, heart attack & chronic heart failure
  • Hyperlipidaemia, diabetes mellitus, and tobacco smoking, alcoholism
  • Stroke & Blood Clot
  • Stomach or Intestinal Ulcer
  • liver problems & Failure
  • Pregnancy
  • Increased Cardiovascular Event Risk
  • kidney disease with likely reduction in kidney function
  • Anaphylactic reactions and serious skin reactions
  • Heart disease, high blood pressure, high cholesterol, diabetes, or if you smoke
  • A history of heart attack, stroke, or blood clot
  • A history of stomach ulcers or bleeding
  • Asthma
  • liver or kidney disease
  • Fluid retention
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