Piprazo is a combination of piperacillin and tazobactum. Piperacillin is an extended-spectrum beta-lactam antibiotic . It is normally used together with a beta-lactamase inhibitor, notably in the combination of piperacillin /tazobactam. Tazobactum is a pharmaceutical drug; it is usually combined with extended spectrum β- lactum antibiotic Piperacillin. It will help to increase the spectrum of Piperacillin, without which the bacteria will degrade the Piperacillin. Tazobactam is a penicillanic acid sulfone derivative with beta-lactamase inhibitory properties.
- Diabetic foot
- Pelvic inflammatory diseases
- Complicated skin infection
- Infection of bone
- Blood or tissue infection affecting whole body of newborn
3.375 g IV every 6 hours; 4.5 g IV every 8 hours has also been used for 7 to 10 days, depending on the nature and severity of the infection.
Piperacillin mechanism involves inhibition of bacterial cell wall synthesis by combining with penicillin binding protein that inhibits the transpeptidation step of peptidoglycan synthesis in bacterial cell walls, thus inhibiting cell wall biosynthesis.
Tazobactam causes inhibition of many beta-lactamses and has limited activity against class I beta-lactamases other than class Ic types.
It is not absorbed orally, and should be given by I.V or I.M. The drug is not concentration dependent in its actions.
It is widely distributed in body fluids, and about 30% is protein bound. In body Piperacillin is metabolized as des-ethyl metabolite and Tazobactam as single metabolite.
The concentration half-life of Piperacillin and tazobactum are 0.7-1.2 hours respectively. Elimination of drug is through kidney by glomerular filteration and tubular secretion. They are excreted in unchanged form in urine as 68 – 80% respectively.
Piprazo is contraindicated in patients with a history of allergy reaction to any of the penicillins, cephalosporins, or beta-lactamase inhibitors.
- Pregnant and lactating patient
- Cautious in patients with low potassium levels
- Cautious in patients with cystic fibrosis, causes fever and rashes in those patients.
- Prolong use causes super infections
- Renal impairment