Paracetamol is a painkilling (analgesic) medicine, also known as acetaminophen, medicine used to treat pain and fever
- Fever & Pain
- Low back pain
- Postoperative pain
- Dental use
- menstrual period
Dose varies according to weight of patient.
For adult patient weighing more than 50 kg: 1-4 gm/day, for 33-50 kg: 15 mg/kg one to four times daily, For children: 7.5-15 mg/kg one to four times daily.
Paracetamol action by block cyclooxygenase (COX) in brain, block release & synthesis of prostaglandins in CNS, inhibit the action of endogenous pyrogens on the heat regulating centres in the brain this causes antipyretic effect.
Paracetamol is well absorbed in the gastrointestinal tract. Oral bioavailability is dose dependant: with larger doses, the hepatic first pass effect is reduced due to overwhelming of the liver enzymatic capacity; and therefore, bioavailability is increased
Paracetamol is distributed throughout the body fluids in a homogeneous way. The analgesic activity is attributable to the small fraction that penetrates into the brain. Paracetamol given at therapeutic doses binds to plasma proteins at less than 20%.
Paracetamol is essentially metabolized in the liver by conjugation with glucuronic acid (55%) and sulfuric acid (35%)
Paracetamol solution for infusion is contraindicated:
- In cases of hypersensitivity to paracetamol or to any of the excipients
- In cases of severe hepatocellular insufficiency
- In patients with hepatic failure or active liver disease.
Use in Pregnancy & Lactation.
- Paracetamol is not contraindicated during pregnancy and in breast-feeding women
Paracetamol infusion should be used with caution in cases of:
- In chronic alcoholism
- severe renal insufficiency
- Hepatocellular insufficiency
- Dehydration, Hypovolemia
- Glucose-6-Phosphate Dehyrogenase (G6PD) deficiency